Discover how long tamoxifen is typically prescribed after breast cancer surgery. Dr. Margileth explains the research underpinning the treatment duration.
David A. Margileth, M.D.:?When tamoxifen was first developed in the early 80s it replaced removal of the ovaries as a hormone manipulation for the treatment of breast cancer.? The initial trials looked at two years of tamoxifen versus no tamoxifen and two years was better than none.? The next trial was a trial of five years versus two years and five years turned out to be a better length of treatment than two years.? The next trial I did was a trial of ten years versus five years and interestingly ten years did not turn out to be better than five years.
So the standard approach at this point in time would be to limit tamoxifen use after primary surgery for breast cancer to five years. If the patient has a particularly bad breast cancer and is post menopausal, one can then ask the question whether further treatment with an aromatase inhibitor is appropriate, but in general five years of tamoxifen would be the time period of giving that drug.
Dr. David A. Margileth practices medical oncology at St. Joesph Hospital in Orange, CA specializing in oncology, hematology, and internal medicine (board certified). His selected area of interest is breast cancer. Dr. Margileth graduated from Baylor College of Medicine in 1971 and has since spent time treating patients at the National Cancer Institute and Methodist Hospital in Houston, TX.
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