Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/287210711?client_source=feed&format=rss
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Tuesday, February 26, 2013
Treat malware as biology to know it better - Miles Maddox 95's blog
Hal Hodson, technology reporter
Classifying different kinds of malware is notoriously hard, but crucial if computer defences are to keep up with the ever-evolving ecosystem of malicious programs. Treating computer viruses as biological puzzle could help computer scientists get a better handle on the wide world of malware.?
Ajit Narayanan and Yi Chen at the Auckland University of Technology, New Zealand, converted the signatures of 120 worms and viruses into an amino acid representation. The signatures are more usually presented in hexadecimals - a base-16 numbering system which uses the digits 0 to 9 as well as the letters a to f - but the amino acid "alphabet" is better suited to machine-learning techniques that can analyse a piece of code to figure out whether it matches a known malware signature.
Generally, malware experts identify and calculate the signatures of new malware, but it can be hard for them keep up. While machine learning can help, it is limited because the hexadecimal signatures can be different lengths: Narayanan's team found that using machine learning to help classify the hexadecimal malware signatures resulted in accuracy no better than flipping a coin.
But some techniques used in bioinformatics for comparing amino acid sequences take differing lengths into account. After applying these to malware, Narayanan's average accuracy for classifying the signatures automatically using machine learning rose to 85 per cent.
Biology might help in other ways too. Narayanan notes that if further study shows malware evolution follows some of the same rules as amino acids and proteins, our knowledge of biological systems could be used to help fight it.
Journal reference: arXiv:1302.3668
Source: http://feeds.newscientist.com/c/749/f/10897/s/28ee8ddf/l/0L0Snewscientist0N0Cblogs0Conepercent0C20A130C0A20Cmalware0Ebiology0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm
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Source: http://milesmaddox.typepad.com/blog/2013/02/treat-malware-as-biology-to-know-it-better.html
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Global Finance Crisis ? The Crisis of Credit Visualized
This short animation might help you to understand one of the core problems of modern capitalism.
The term financial crisis is applied broadly to a variety of situations in which some financial institutions or assets suddenly lose a large part of their value. In the 19th and early 20th centuries, many financial crises were associated with banking panics, and many recessions coincided with these panics. Other situations that are often called financial crises include stock market crashes and the bursting of other financial bubbles, currency crises, and sovereign defaults. Financial crises directly result in a loss of paper wealth; they do not directly result in changes in the real economy unless a recession or depression follows.
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Source: http://www.videosfortruth.com/global-finance-crisis-the-crisis-of-credit-visualized/
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Jodi Arias set to be grilled on stand in murder trial
Tom Tingle / The Arizona Republic via AP
Prosecutor Juan Martinez asks defendant Jodi Arias a question about her diary during cross examination testimony in Maricopa County Superior Court in Phoenix.
By Brian Skoloff, The Associated Press
Jodi Arias resumes testimony Monday in her Arizona murder trial after the start of a withering cross-examination last week by a prosecutor working to poke holes in her numerous stories.
She is charged in the June 2008 stabbing and shooting death of her lover in his suburban Phoenix home. Arias claims self-defense, while authorities say she planned the attack on Travis Alexander in a jealous rage. Testimony has been ongoing since early January.
Arias, 32, lost a bid last week aimed at getting a reprieve from a potential death sentence if convicted of first-degree murder after the Arizona Supreme Court swiftly denied her motion that claimed a detective committed perjury in the case. Her attorneys have filed multiple motions for mistrials, all of which have been denied.
She was set to resume testimony Monday for her 10th day on the witness stand.
Last week, prosecutor Juan Martinez hammered Arias with intense questioning about her inability to recall crucial details in the case, yet noted it was puzzling that she can remember "what kind of coffee you bought at Starbucks sometime back in 2008."
Arias smirked at times while Martinez stammered in frustration, and the judge admonished both to stop talking over each other as the questioning grew heated and the two traded barbs.
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Martinez resumes his cross-examination Monday likely continuing to focus on Arias' repeated lies.
Arias first told authorities she knew nothing about Alexander's death, then later blamed it on masked intruders before eventually settling on self-defense.
She said she was scared of being arrested, had been contemplating suicide and didn't want to sully Alexander's name with accounts of his violent behavior and lurid details of their sexual relationship, given his public persona as a devout Mormon who was saving himself for marriage.
Of the day she killed Alexander, Arias says she remembers him in a rage, body slamming her and chasing her around his home.
She said she grabbed a gun from his closet, and fired it as they tussled, but didn't know if she hit him. She had no explanation for the 27 stab and slash wounds he suffered, or his slit throat, or how he ended up stuffed in his shower.
According to court records, however, she previously told police before her trial began that Alexander was unconscious after she shot him, but then "crawled around and was stabbed."
She says she remembers putting a knife in the dishwasher and disposing of the gun in the desert as she drove from Arizona on her way to Utah. And she immediately began planning an alibi.
Arias' grandparents reported a .25 caliber handgun stolen from their Northern California house about a week before the killing ? the same caliber used to shoot Alexander ? but Arias claims to know nothing about the burglary. She says she brought no weapons to Alexander's home on the day she killed him, undercutting the prosecution's theory of premeditation.
? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Sunday, February 24, 2013
Mobile Nations podcasting update: What's new for 2013!
Hey everyone! It's time for a mighty Mobile Nations podcast network update, and a peak at some really cool stuff we have planned for 2013! First of all, we have all-new album art for the shows. The original concept was created by superstar designer Marc Edwards of Bjango to be crisp, clean, and modern. It's tough to make a whole catalog of shows consistent yet retain all their individual personalities. With Marc's help, I think we've nailed it. And by popular demand, we've even added a small TV logo to the bottom of all the video podcast album art so you can distinguish them from their audio counterparts at a glance. We absolutely love them, and we hope you do too. (And yes, we'll be making all of them available as HiDPI/Retina wallpaper for your phones and tablets later this week!)
If you haven't recently, please make sure you leave a review and rating for your favorite Mobile Nations shows, where ever and when ever you can. It encourages services (like iTunes) to feature us, that helps us get more great listeners and viewers like you, and we appreciate it a lot!
Now on with the shows!
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Source: http://feedproxy.google.com/~r/androidcentral/~3/c-F9hD1f5TA/story01.htm
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Transparent sensor could turn your wall into a camera
A new type of image sensor has been developed by Austrian researchers that takes the form of a transparent film that could be placed over windows, walls, or displays. It's still very much a work in progress, but could represent the shape of webcams to come.
Many are familiar with the frustrations of user-facing cameras. Perhaps the most irritating thing is that you can't look someone in the eye when you video chat ? a nice problem to have, to be sure, but still a problem. And with things like the Kinect and Leap changing how we interact with computers, having an actual camera stuck to your monitor or phone seems distinctly 20th century.
This new form of sensor may be a hint at how devices of the future see us: By detecting the light patterns cast on just about any surface ? though it's so early in development that they haven't even given it a name yet (unless "thin-film luminescent concentrator" counts).
The transparent film intercepts a tiny amount of the light passing through it, channeling to the edges of the sheet. There, an array of photosensors picks it up ? and by some complicated math that computes what is bright and dark depending on the way the light hits different sensors, they can reconstruct the image striking the whole sheet.
Of course, the image would have to be focused on the display itself, the way an image has to be in focus on a piece of film or a traditional image sensor. Since you can't put a huge lens in front of the display (or project the image directly onto the film, as shown in their test setup), chances are this new sensor will be getting a fairly fuzzy picture of what's in front of it.
But you don't need a sharp picture for every purpose: Gestures could be detected, for instance, or the general ambient light, or the location of the user ? all without a "real" camera. And it doesn't have to be on a screen; It could easily be put on a window or desk, making those into light-sensitive surfaces.
Right now the resolution is extremely limited, it only produces greyscale images, and there's a lot of noise. But this is just a proof of concept; Improving the quality is the next step (though it is hardly a trivial one).
The paper describing the technology, by Alexander Koppelhuber and Oliver Bimber of Johannes Kepler University Linz in Austria, appeared in Optics Express and can be downloaded for free from the journal.
via Gizmag
Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.
Source: http://www.nbcnews.com/technology/gadgetbox/transparent-sensor-could-turn-your-wall-camera-1C8503330
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Unemployed complain they need a job to find a job
NEW YORK (AP) -- Help wanted. Qualifications: Must already have a job.
It's a frustrating catch for those out of work in an era of high unemployment: looking for a job, only to find that some employers don't want anyone who doesn't already have one.
But after four years of above-average joblessness in the U.S., efforts to bar such practices by employers have met with mixed results.
While New Jersey, Oregon and Washington, D.C., have passed laws making it illegal to discriminate against the unemployed, New York City's billionaire-businessman mayor vetoed on Friday what would have been the most aggressive such measure in the country. Similar proposals have stalled in more than a dozen other states and Congress.
Advocates for the unemployed say such hiring practices are unfair, particularly to those who have been laid off because of the economic crunch and not through any fault of their own. Businesses, though, say that the extent of such practices is exaggerated, hiring decisions are too complicated to legislate, and employers could end up defending themselves against dubious complaints.
Nationally, more than 1 in 3 unemployed workers has been looking for at least six months, according to the federal Bureau of Labor Statistics.
Janet Falk said that when she applied for a public-relations job at a New York law firm two years ago, the recruiter told her she wouldn't be considered because she had been out of work for more than three months. The recruiter was being paid to find candidates who were in jobs or just out of them.
"My personal view is that hiring is like musical chairs, and if only the people who are already on the dance floor are playing, then the long-term unemployed can't get in the game," said Falk, who was laid off four years ago. She now runs her own consulting business.
An October 2011 search of New York City-based job listings found more than a dozen that explicitly required candidates to be employed, Manhattan Borough President Scott Stringer's office said. A broader review that year by the National Employment Law Project found 150 ads that were restricted to or aimed at people currently working.
As for why, experts say employers may think that unemployed applicants' skills have atrophied, that they lost their jobs because of their own shortcomings, or that they will jump at any job offer and then leave as soon as something better comes along.
But "'don't apply, don't even try' is the opposite of American values," New York City Council Speaker Christine Quinn said when the measure passed last month. She said Friday that she expects the City Council will override Mayor Michael Bloomberg's veto within a month.
Bloomberg called the measure a well-intended but misguided effort that would create more lawsuits than jobs.
"Hiring decisions frequently involve the exercise of independent, subjective judgment about a prospective employee's likely future performance," he said in a statement.
And unlike other characteristics that employers are generally banned from considering, such as an applicant's race, religion or gender, "the circumstances surrounding a person's unemployment status may, in certain situations, be relevant to employers when selecting qualified employees," he said.
Business groups say that no-unemployed-applicants-need-apply ads represent a tiny fraction of the millions of job openings nationwide each year.
One 2011 listing that got city lawmakers' attention ? it required that applicants for an opening as a New York legal secretary "must be currently employed" ? was mistakenly written that way, said William Alcott, a lawyer for the firm that posted it, McGuireWoods LLP.
"It was not our policy then and isn't our policy now," he said this week.
Like other measures that have passed, the New York City one would ban help-wanted ads that say unemployed applicants won't qualify. It would also more generally prohibit employers from refusing to hire candidates because they are out of work.
But New York's measure would go further than the others by letting rejected applicants sue employers for damages.
Companies see it as government meddling and "creating another basis for unmerited lawsuits against employers," said Kathryn Wylde, president of the Partnership for New York City, an influential business group.
President Barack Obama proposed in 2011 to make it illegal to refuse to consider unemployed applicants.
New Jersey in 2011 became the first state to outlaw the practice. The state Labor Department has gotten one complaint so far and cited a company for an ad that excluded jobless applicants; the case is not yet resolved, the agency said this week.
Oregon and the District of Columbia followed suit last year, while 15 other states considered similar proposals, according to the National Conference of State Legislatures. Gov. Jerry Brown vetoed such a measure in California last fall, indicating he wasn't happy with changes made to it.
___
Associated Press writer Rema Rahman contributed to this report from Trenton, N.J.
___
Follow Jennifer Peltz at http://twitter.com/jennpeltz
Source: http://news.yahoo.com/unemployed-complain-job-job-191738634.html
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Falling lamb prices make UK, Irish sheep farmers fear for future
LONDON (Reuters) - Sheep farmers in Britain and Ireland fear for their future as oversupply of lamb in Europe drags farm-gate prices to three-year lows while production costs soar, giving efficient New Zealand exporters a vital edge.
Most British sheep farmers have been selling at a loss since November because an influx of cheap imports coincided with the delayed sales of home-grown lambs that had been held up by wet weather causing poor feeding conditions.
Meanwhile, much of the European Union, the biggest market for British lamb, is in recession.
Lamb prices at British farms were down 24 percent year-on-year in early February while Ireland recorded a 20 percent drop.
Britain and Ireland are the EU's top lamb producers and major exporters alongside world leaders New Zealand and Australia.
But farmers and analysts say falling incomes could push hundreds to leave the business and thousands more to reduce their flocks, making the animal that shapes much of the current landscape of the islands, through its grazing, a rarer sight.
"If this trend continues, and producers are forced to sell lambs at less than the cost of production, then ultimately they will look at alternative ways of making a living," said Charles Sercombe, a sheep breeder in central England in charge of livestock issues for Britain's National Farmers Union (NFU).
The drop in farm gate prices - to 3.40 pounds per kg ($2.35 per lb)- has yet to show on British supermarket shelves, where lamb fetches between 7 and 15 pounds a kg. According to the NFU, while December wholesale prices for legs of lamb slid 17 percent from a year ago, retail prices edged down only 2 percent.
"Farmers' costs are rising, but retailers' costs are too," said Richard Dodd, spokesman for the British Retail Consortium, adding that the country's supermarkets regularly ran promotions on lamb but that higher costs for processing, transport and running stores needed to be reflected in headline shop prices.
Input costs for British and Irish sheep farmers have increased by around 30 percent in the past five years, with feed, fuel and fertilisers biting particularly hard.
"Those are the three things that have really put the guys under pressure here with the reduction in (lamb) price," said Gabriel Gilmartin, president of the Irish Cattle and Sheep Farmers' Association.
The situation for producers could get worse as New Zealand has leeway in its export quotas to further increase shipments to the EU, where appetite for lamb remains solid but incomes are squeezed.
FROM SHORTAGE TO OVERSUPPLY
Despite a strengthening currency, export-driven New Zealand farmers can produce lamb more cheaply than those in Britain and Ireland, largely through economies of scale.
In Ireland a large farm might have 500 to 600 sheep, compared with 3,000 to 5,000 in New Zealand, Gilmartin said.
"There is too much fragmentation of land in Ireland and the holdings are too small," he said.
Britain has been importing lamb from the Southern Hemisphere for over a century to guarantee supply at any season, with peak shipments traditionally arriving in the first half of the year, when domestic supply is lowest.
But the heavy rain of 2012 delayed Britain's peak of production by two months because lambs do not thrive on soaked grass, as they get less nutrients and are prone to diseases.
When these lambs came to market late last year, New Zealand imports had increased by over 30 percent from the previous year, according to data shared by trade body the English Beef and Lamb Executive (Eblex).
This increase came after extremely tight global supplies in 2011 sent prices to record highs and prompted a jump in output.
But consumer expenditure on lamb in Europe has since remained roughly static and the higher volumes sold fetched lower prices per kg, said Eblex senior analyst Paul Heyhoe.
Mike Petersen, chairman of New Zealand's trade body for beef and lamb, said average lamb prices were expected to drop by a quarter in the country this year.
"There is no doubt that with a soft market, and a number of carryover UK lambs from the wet winter, pricing has been softer than all of us would like," he said.
The agriculture ministry forecast last month that average incomes for English farms with grazing livestock would fall by up to 52 percent in 2012/13 to between 14,000 and 18,000 pounds.
The ministry cited lower sheep values and higher feed costs.
Phil Stocker, chief executive of Britain's National Sheep Association, warned that if farm gate prices did not pick up within six months, 2 to 3 percent of the country's 65,000 sheep farmers could decide to leave the business entirely, while a majority may shift activity towards crops, cattle or dairy.
"We could see the confidence that's built up in the last two or three years come to a halt, which would be a real shame, especially when global signals are still fairly strong and when, for environment and landscape purposes, people are saying we need grazing animals," he said. ($1 = 0.6555 British pounds)
(Writing by Natalie Huet, additional reporting by Mantik Kusjanto in Wellington; Editing by Veronica Brown and Anthony Barker)
Source: http://news.yahoo.com/falling-lamb-prices-uk-irish-sheep-farmers-fear-170539787.html
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6 leaking tanks are Hanford nuke site's latest woe
FILE -- In this March 23, 2004 file photo, workers at the tank farms on the Hanford Nuclear Reservation near Richland, Wash., measure for radiation and the presence of toxic vapors. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/Jackie Johnston, File)
FILE -- In this March 23, 2004 file photo, workers at the tank farms on the Hanford Nuclear Reservation near Richland, Wash., measure for radiation and the presence of toxic vapors. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/Jackie Johnston, File)
FILE - In this July 14, 2010 photo, workers at the Hanford nuclear reservation work around a a tank farm where highly radioactive waste is stored underground near Richland, Wash. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/Shannon Dininny, File)
FILE -- In this Feb. 19, 2013 file photo, Sen. Ron Wyden, D-Ore., right, tours a facility to treat contaminated groundwater with Energy Department manager Matt McCormick on the Hanford nuclear reservation near Richland, Wash. The facility is a key to cleaning up the highly contaminated site. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/Shannon Dininny, File)
FILE -- This photo provided by the U.S. Dept. of Energy, shows the construction of a "tank farm" to store nuclear waste in 1944 on the Hanford nuclear reservation near Richland, Wash. It is one of collection of photos documenting life in and around the reservation from 1943-1967. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/U.S. Department of Energy, File)
FILE -- In this Sept. 18, 2012 file photo, then-Gov. Chris Gregoire makes her way down a set of stairs at the Hanford Vitrification Plant in Richland, Wash. Six underground radioactive waste tanks at the nation's most contaminated nuclear site are leaking, Gov. Jay Inslee said Friday, Feb. 22, 2013. Inslee made the announcement after meeting with federal officials in Washington, D.C. Last week it was revealed that one of the 177 tanks at south-central Washington's Hanford Nuclear Reservation was leaking liquids. Inslee called the latest news "disturbing." (AP Photo/The Tri-City Herald, Richard Dickin, File) LOCAL TV OUT; LOCAL RADIO OUT KONA
YAKIMA, Wash. (AP) ? Federal and state officials say six underground tanks holding a brew of radioactive and toxic waste are leaking at the country's most contaminated nuclear site in south-central Washington, raising concerns about delays for emptying the aging tanks.
The leaking materials at Hanford Nuclear Reservation pose no immediate risk to public safety or the environment because it would take perhaps years for the chemicals to reach groundwater, Washington Gov. Jay Inslee said Friday.
But the news has renewed discussion over delays for emptying the tanks, which were installed decades ago and are long past their intended 20-year life span.
"None of these tanks would be acceptable for use today. They are all beyond their design life. None of them should be in service," said Tom Carpenter of Hanford Challenge, a Hanford watchdog group. "And yet, they're holding two-thirds of the nation's high-level nuclear waste."
Just last week, state officials announced that one of Hanford's 177 tanks was leaking 150 to 300 gallons a year, posing a risk to groundwater and rivers. So far, nearby monitoring wells haven't detected higher radioactivity levels.
Inslee then traveled to Washington, D.C., to discuss the problem with federal officials, learning in meetings Friday that six tanks are leaking.
The declining waste levels in the six tanks were missed because only a narrow band of measurements was evaluated, rather than a wider band that would have shown the levels changing over time, Inslee said.
"It's like if you're trying to determine if climate change is happening, only looking at the data for today," he said. "Perhaps human error, the protocol did not call for it. But that's not the most important thing at the moment. The important thing now is to find and address the leakers."
Department of Energy spokeswoman Lindsey Geisler said there was no immediate health risk and that federal officials would work with Washington state to address the matter.
Regardless, Sen. Ron Wyden, the new chairman of the Senate Energy and Natural Resources Committee, will ask the Government Accountability Office to investigate Hanford's tank monitoring and maintenance program, said his spokesman, Tom Towslee.
The federal government built the Hanford facility at the height of World War II as part of the Manhattan Project to build the atomic bomb. The remote site produced plutonium for the bomb dropped on Nagasaki, Japan, and continued supporting the nation's nuclear weapons arsenal for years.
Today, it is the most contaminated nuclear site in the country, still surrounded by sagebrush but with Washington's Tri-Cities of Richland, Kennewick and Pasco several miles downriver.
Several years ago, workers at Hanford completed two of three projects deemed urgent risks to the public and the environment, removing all weapons-grade plutonium from the site and emptying leaky pools that held spent nuclear fuel just 400 yards from the river.
But successes at the site often are overshadowed by delays, budget overruns and technological challenges. Nowhere have those challenges been more apparent than in Hanford's central plateau, home to the site's third most urgent project: emptying the tanks.
Hanford's tanks hold some 53 million gallons of highly radioactive waste ? enough to fill dozens of Olympic-size swimming pools ? and many of those tanks are known to have leaked in the past. An estimated 1 million gallons of radioactive liquid has already leaked there.
The cornerstone of emptying the tanks is a treatment plant that will convert the waste into glasslike logs for safe, secure storage. The plant, last estimated to cost more than $12.3 billion, is billions of dollars over budget and behind schedule. It isn't expected to being operating until at least 2019.
Washington state is imposing a "zero-tolerance" policy on radioactive waste leaking into the soil, Inslee said. So given those delays and the apparent deterioration of some of the tanks, the federal government will have to show that there is adequate storage for the waste in the meantime, he said.
"We are not convinced of this," he said. "There will be a robust exchange of information in the coming weeks to get to the bottom of this."
Inslee and Oregon Gov. John Kitzhaber, both Democrats, have championed building additional tanks to ensure safe storage of the waste until the plant is completed.
Wyden, D-Ore., toured the site earlier this week. He said he shares the governors' concerns about the integrity of the tanks but he wants more scientific information to determine it's the correct way to spend scarce money.
Wyden noted the nation's most contaminated nuclear site ? and the challenges associated with ridding it of its toxic legacy ? will be a subject of upcoming hearings and a higher priority in Washington, D.C.
The federal government already spends $2 billion each year on Hanford cleanup ? one-third of its entire budget for nuclear cleanup nationally. The Energy Department has said it expects funding levels to remain the same for the foreseeable future, but a new Energy Department report released this week calls for annual budgets of as much as $3.5 billion during some years of the cleanup effort.
There are legal, moral and ethical considerations to cleaning up the Hanford site at the national level, Inslee said, adding that he will continue to insist that the Energy Department completely clean up the site.
___
Associated Press writer Dina Cappiello in Washington, D.C., contributed to this report.
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Video: Researchers develop protein 'passport' that help nanoparticles get past immune system
Video: Researchers develop protein 'passport' that help nanoparticles get past immune system
Friday, February 22, 2013The body's immune system exists to identify and destroy foreign objects, whether they are bacteria, viruses, flecks of dirt or splinters. Unfortunately, nanoparticles designed to deliver drugs, and implanted devices like pacemakers or artificial joints, are just as foreign and subject to the same response.
Now, researchers at the University of Pennsylvania School of Engineering and Applied Science and Penn's Institute for Translational Medicine and Therapeutics have figured out a way to provide a "passport" for such therapeutic devices, enabling them to get past the body's security system.
The research was conducted by professor Dennis Discher, graduate students Pia Rodriguez, Takamasa Harada, David Christian and Richard K. Tsai and postdoctoral fellow Diego Pantano of the Molecular and Cell Biophysics Lab in Chemical and Biomolecular Engineering at Penn.
It was published in the journal Science.
"From your body's perspective," Rodriguez said, "an arrowhead a thousand years ago and a pacemaker today are treated the same ? as a foreign invader.
"We'd really like things like pacemakers, sutures and drug-delivery vehicles to not cause an inflammatory response from the innate immune system."
The innate immune system attacks foreign bodies in a general way. Unlike the learned response of the adaptive immune system, which includes the targeted antibodies that are formed after a vaccination, the innate immune system tries to destroy everything it doesn't recognize as being part of the body.
This response has many cellular components, including macrophages ? literally "big eaters" ? that find, engulf and destroy invaders. Proteins in blood serum work in tandem with macrophages; they adhere to objects in the blood stream and draw macrophages' attention. If the macrophage determines these proteins are stuck to a foreign invader, they will eat it or signal other macrophages to form a barrier around it.
Drug-delivery nanoparticles naturally trigger this response, so researchers' earlier attempts to circumvent it involved coating the particles with polymer "brushes." These brushes stick out from the nanoparticle and attempt to physically block various blood serum proteins from sticking to its surface.
However, these brushes only slow down the macrophage-signaling proteins, so Discher and colleagues tried a different approach: Convincing the macrophages that the nanoparticles were part of the body and shouldn't be cleared.
In 2008, Discher's group showed that the human protein CD47, found on almost all mammalian cell membranes, binds to a macrophage receptor known as SIRPa in humans. Like a patrolling border guard inspecting a passport, if a macrophage's SIRPa binds to a cell's CD47, it tells the macrophage that the cell isn't an invader and should be allowed to proceed on.
Penn's Dennis Discher explains how his lab designed a protein that acts a "passport" for the body's immune system. Nanoparticles equipped with this passport last longer in the bloodstream than equivalent particles without it.Credit: Kurtis Sensenig, University of Pennsylvania
Since the publication of that study, other researchers determined the combined structure of CD47 and SIRPa together. Using this information, Discher's group was able to computationally design the smallest sequence of amino acids that would act like CD47. This "minimal peptide" would have to fold and fit well enough into the receptor of SIRPa to serve as a valid passport.
After chemically synthesizing this minimal peptide, Discher's team attached it to conventional nanoparticles that could be used in a variety of experiments.
"Now, anyone can make the peptide and put it on whatever they want," Rodriguez said
The research team's experiments used a mouse model to demonstrate better imaging of tumors and as well as improved efficacy of an anti-cancer drug-delivery particle.
As this minimal peptide might one day be attached to a wide range of drug-delivery vehicles, the researchers also attached antibodies of the type that could be used in targeting cancer cells or other kinds of diseased tissue. Beyond a proof of concept for therapeutics, these antibodies also served to attract the macrophages' attention and ensure the minimal peptide's passport was being checked and approved.
"We're showing that the peptide actually does inhibit the macrophage's response," Discher said. "We force the interaction and then overwhelm it."
The test of this minimal peptide's efficacy was in mice that were genetically modified so their macophages had SIRPa receptors similar to human. The researchers injected two kinds of nanoparticles ? ones carrying the peptide passport and ones without ? and then measured how fast the mice's immune system cleared them.
"We used different fluorescent dyes on the two kinds of nanoparticles, so we could take blood samples every 10 minutes and measure how many particles of each kind were left using flow cytometry," Rodriguez said. "We injected the two particles in a 1-to-1 ratio and 20-30 minutes later, there were up to four times as many particles with the peptide left."
Even giving therapeutic nanoparticles an additional half-hour before they are eaten by macrophages could be a major boon for treatments. Such nanoparticles might need to make a few trips through the macrophage-heavy spleen and liver to find their targets, but they shouldn't stay in the body indefinitely. Other combinations of exterior proteins might be appropriate for more permanent devices, such as pacemaker leads, enabling them to hide from the immune system for longer periods of time.
While more research is necessary before such applications become a reality, reducing the peptide down to a sequence of only a few amino acids was a critical step. The relative simplicity of this passport molecule to be more easily synthesized makes it a more attractive component for future therapeutics.
"It can be made cleanly in a machine," Discher said, "and easily modified during synthesis in order to attach to all sorts of implanted and injected things, with the goal of fooling the body into accepting these things as 'self.'"
###
University of Pennsylvania: http://www.upenn.edu/pennnews
Thanks to University of Pennsylvania for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Saturday, February 23, 2013
Australia have more reason to be happy than India: Kapil
Chennai: Former India captain and coach Kapil Dev spoke to The Telegraph at the Hyatt Regency on Friday evening.
Q Your thoughts at the end of the first day of the India-Australia series...
A At 316/7 at close, I think Australia have more reason to be happy than India. Humne unko nikal jaane diya.
But we got two wickets before the close in the space of a few minutes... The massive Michael Clarke-Moises Henriques partnership did end, didn?t it?
Agreed, but look where Australia were at the fall of the fifth wicket.
Just how far did you expect Australia to go after Ravichandran Ashwin had reduced them to five down for 153?
I was hoping India would bowl them out for 230-240, at the most... Australia have gone past 300 and, with Clarke still there, their innings could stretch to 400. That would be a very good score on this wicket. I stress this wicket.
It was supposed to be Harbhajan Singh?s day, but Ashwin upstaged him so comprehensively...
Obviously, Ashwin bowled very well, but he could do even better with a slightly different line... It?s good that he didn?t try too many things, but kept it simple... In the Test series against England, Ashwin would try a lot of things... The doosra, the carrom ball... On a wicket such as this, all you need to do is bowl at one spot and the wicket will do the rest.
Did the pressure of yet another comeback and the 100th-Test milestone get to Harbhajan?
Harbhajan?s struggling... One reason for that being the loop of old is missing... I got the impression that he?d been playing a lot of limited overs cricket.
What about the pressure?
Instead of talking about the pressure, I?d say this is another opportunity for Harbhajan.
Your 100th Test was in Karachi over 23 years ago. What?s the stand-out memory?
(Laughs) That my 100th Test was Sachin Tendulkar?s debut! Nobody remembers my 100th, but everybody remembers his maiden Test... Not just stand-out, I suppose the Sachin debut is the only memory even I have of what surely was a landmark Test for me.
Having been wowed by young Bhuvneshwar Kumar in the ODIs and T20 Internationals, you must be happy that he?s made his Test debut...
Let me put it this way, I would have been happier had he made his debut on a helpful wicket... But theek hai, debut hua.
What?s your take on Clarke?s superb unbeaten 103?
Clarke has again led from the front and, clearly, is the world?s No.1 batsman at this point in time.
Captaincy hasn?t affected Clarke?s batting one bit...
He?s in the midst of a purple patch... That?s when nothing goes wrong.
We lost the last Test series at home, to England... Is there a favourite in this one?
I expect India to do well, but things could change if we can?t pull it back here with our batting... The England team, in my opinion, had more maturity than this Australian side.
Lastly... Is there a message for Mahendra Singh Dhoni and his men?
Bowling-wise, we?ve lost the plot... Now, get it right with the batting. If we don?t, then...
Source: http://www.telegraphindia.com/1130223/jsp/sports/story_16596338.jsp
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CloudOn Announces Version 4.0; Officially Brings Microsoft Office to Android
CloudOn Launches Version 4.0, Bringing Increased Productivity to Android Smartphones
CloudOn now lets users create, edit, review and share documents, spreadsheets and presentations on the world?s largest smartphone platform
Palo Alto, Calif. ? (February 21, 2013) ? Today CloudOn, the global leader in mobile productivity, is launching version 4.0 worldwide. CloudOn has completely optimized Microsoft Office for Android smartphones, with additional productivity features to provide the most user-friendly experience in creating, reviewing, editing, sharing and accessing information about documents from your phone.
Bringing continued innovation to the productivity space, CloudOn is bringing the same functionality of its iPhone app to Android phones, the largest smartphone platform across the globe. Always listening and responding to its vibrant user base, CloudOn has also added in highly requested features to version 4.0 such as landscape mode for easier viewing and revisions. Beyond simply optimizing Word, PowerPoint and Excel, the Android app provides users with contextual tools and additional editing options to make files more like living documents and less like individual cells.
Available for Android phones including the Samsung Galaxy S III, Galaxy Nexus 4G LTE, Galaxy Nexus, Galaxy Note, Galaxy Note II and Galaxy S II Skyrocket, CloudOn continues to be the leading global productivity company with 3.5 million downloads to date.
For the first-time ever, CloudOn comes to Android smartphones with the following features:
? Android Customized Ribbon: The Microsoft Office ribbon is tailored to the Android screen, so touch-based functions like selecting font size, turning on track changes or creating a table are dead simple for users across all editing options.
? CloudOn FileSpace: A FileSpace is a place to add notes and view all activity on a single file, including edits, for real-time updates on documents.
? Support for both Portrait and Landscape view: View documents in either portrait of landscape mode, for easy editing on the go
? Accessibility: Easily share files and view word, PPT or excel documents directly from your email, Dropbox, Box, Google Drive and SkyDrive.
? Notes: Quickly and easily add notes to any Microsoft Office document on an Android. These notes can be shared and viewed by all collaborators.
?We are thrilled that CloudOn is now available across the entire Android ecosystem, and are excited to be able to reach more of our loyal customer base,? said CloudOn CEO Milind Gadekar. ?In addition to bringing Microsoft Office to Android phones, we are excited to give our users a better way to create content, and also access the critical contextual information around documents as we continue to grow our productivity offering.?
CloudOn for iOS is available now for download worldwide. To download CloudOn for the iPhone, iPad or iPad mini, visit: http://itunes.apple.com/app/cloudon/id474025452
CloudOn for Android is available now for download worldwide. To download CloudOn for Android tablets, visit: https://play.google.com/store/apps/d...cloudon.client
To learn more about CloudOn, visit: CloudOn | brings Microsoft Office(R) to your favorite device
About CloudOn:
CloudOn is a Silicon Valley based startup improving mobile productivity. CloudOn makes it easier than ever to create, review, edit and share the documents you need on the devices you love. For more information visit: CloudOn | brings Microsoft Office(R) to your favorite device, or follow us on Twitter @cloudoninc.
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Donovan speaks publicly for 1st time in?2 months
Ah, citizen journalism. It can change the world, as we know.
Clearly, Landon Donovan?s words spoken to a USC business class Wednesday are not somehow historic in the way, say, the citizen journalist?s pictures that showed Rodney King?s brutal beating were, or the vital chronicles of the Arab Spring.
But for soccer supporters, this represents the first we?ve heard from Donovan since the moments after his LA Galaxy won MLS Cup last December.
Donovan appeared in a regular University of Southern California forum called ?The Competitive Edge.?? A student identified on Twitter as Jesse Xiao went to the social media forum to alert the world that, among other things, Donovan did want to get back into the national team.
Have a nice day, Jurgen Klinsmann! That should put a little more pep in his step.
Donovan has taken time off since MLS Cup; he recently announced through the Galaxy a return to the MLS club set for late March.
(MORE: Landon Donovan sets return for late next month)
While the quotes attributed to Donovan have yet to be corroborated, the U.S. national team and LA Galaxy all-time leading scorer has ample ability through either organization to disclaim the words attributed to him. Presumably, he would have by now if any were less than accurate.
Among what Xiao tweeted:
(MORE: Jurgen Klinsmann talks about Landon Donovan?s career midlife crisis)?
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Djibouti president's control of parliament at stake in election
DJIBOUTI (Reuters) - Djibouti's leader could lose control of parliament for the first time in a legislative election on Friday, raising the risk of political paralysis in a Red Sea ally of the West's fight against militant Islam.
It is the first contested parliamentary vote in Djibouti - which hosts the United States' only military base in Africa - since 2003 when President Ismail Omar Guelleh's party swept all 65 seats in a poll marred by allegations of fraud.
Support for the opposition Union of National Salvation (USN) alliance surged in the run-up to the election, polls have shown, and the group's rallies in the capital have drawn large crowds.
"The time for change has come. Djibouti's opposition has never been better prepared for victory," USN spokesman Daher Ahmed Farah told Reuters after casting his vote.
Voting was generally peaceful as anti-riot police patrolled the city's normally traffic-choked streets. Results were expected late on Friday or in the early hours of Saturday.
In power since 1999, Guelleh has effectively presided over a one-party state for his last 10 years in the former French colony, whose port is used by foreign navies patrolling busy shipping lanes in the Gulf of Aden to fight piracy.
Djibouti counts chaotic Somalia, a haven for al Qaeda-affiliated Islamist rebels, among its neighbors.
There have been calls from some voters for Guelleh to form a coalition government if the opposition wins the election.
"Guelleh is president of all Djiboutians and he should join forces with the opposition if it wins this election to avoid institutions becoming paralyzed," Awa Soubaneh, a teacher, said.
Government supporters say an opposition victory would destabilize the tiny country of about 920,000 people. Some voters expressed fears the vote would either be rigged or disputed by the losing camp.
"I pray to God there are no clashes and that fair play prevails between the government and its opponents," said university student Abdillahi Atteyeh Mohamed after voting.
Formed in December, the USN bloc comprises the Republican Alliance for Development, the Djibouti Development Party and the National Democratic Party.
The opposition boycotted a parliamentary election in 2008 and then refused to field a candidate in the 2011 presidential election, saying that the vote would not be free and fair.
The opposition's main goal is to overturn what they say is Guelleh's policy to stifle dissent and the right to assembly.
In February 2011, galvanized by the success of Arab Spring revolts that toppled dictators in Egypt and Tunisia, anti-government demonstrators in Djibouti demanded Guelleh step down and clashed with riot police.
(Writing by Richard Lough; Editing by James Macharia)
Source: http://news.yahoo.com/djibouti-presidents-control-parliament-stake-election-140639173.html
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Prepare Yourself for the Invasion with the Zombies: Run or Kill Game for Android
Nis, Serbia and Montenegro, February 21, 2013 --( PR.com )-- By playing "Zombies: Run or Kill" game you fight for survival against endless waves of walkers. These zombies were made as really annoying and stubborn creatures,...
Nis, Serbia and Montenegro, February 21, 2013 --(PR.com)-- By playing "Zombies: Run or Kill" game you fight for survival against endless waves of walkers. These zombies were made as really annoying and stubborn creatures, fighting hard and making you not let go of your phone for hours, until you destroy them all. The game was made in the Unity Game Engine.
Game-play may seem simple? zombies come from all over the place and you should try to endure as long as possible not to be killed ? but it?s harder than it looks. There are different weapons from which you can choose, such as gun, riffle, chainsaw, light saber and machine gun. In order for the zombie hordes to be destroyed, you should play the game wisely. With every zombie killed, you upgrade your weapons and get new missions to fulfill.
This is a relatively fresh game on the Android market, and the version for iOS is expected anytime soon. The game is new, but it already has a lot of fans and more than 300,000 downloads on the Google play market. Plus, there is a version of this game on the Amazon market, for Kindle devices. And this is what people who've played this game said. "This kind of quality is hard to find in games and it being free makes it now my favorite and most played game on my phone," said Trinity Carter, who is only one of the satisfied users of this game.
https://play.google.com/store/apps/details?id=com.zombieshootergame.zombierunorkill&
Contact Information:
Peaksel D.O.O.
Milica Denic
+381/60 555 15 89
Contact via Email
Click here to read the full story: Prepare Yourself for the Invasion with the Zombies: Run or Kill Game for Android
Press Release Distributed by PR.com
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Sunday, February 17, 2013
Police: 6 arrested for shooting out 100 windows
KEARNS ? Police have arrested six people for a crime spree that spanned across three cities that amounted to tens of thousands of dollars in damage.
Around 10:30 p.m. Friday night, police began receiving calls of car and home windows being blown out with a BB gun.
The calls came in from across a 20-square mile area west of Bangerter, throughout which more than 100 windows were shattered. Police estimated the damages would cost between $40,000 and $50,000 total.
In West Valley, police said they received 40 to 50 reports of shattered windows; in Kearns, another 40 or so reports came through; and in West Jordan, about 10 were reported.
Some of the victims led police to the alleged vandals: 18-year-old Curtis Ellefsen, 19-year-old Ricardo Vega and four juveniles.
Ellefsen and Vega were each booked into the Salt Lake County Jail for investigation of felony criminal mischief. The three 17-year-olds and one 16-year-old were arrested and booked into juvenile detention.
Unified police detective Ken Hansen said four to five BB guns were also recovered.
Police said a witness saw the six vandalizing the area and called police with a vehicle description.
"I think it was just a group of young adults and juveniles having their version of a good time," said West Valley Police Department Lieutenant Michael Coleman. "Unfortunately, it cost a lot of other people a lot of money."
One victim, Maryan, of West Valley, expects to pay $120 for the damage to her car. Other car repairs she had planned to do will now have to wait, she said.
"It's going to cost a lot of money because insurance isn't going to fix less than $500, and I have to fix it myself," Maryan said.
She said the arrests give her some peace of mind.
"I'm glad those who do bad things have been arrested, and I'm glad (police) are doing good things," she said.
Sandra Yi, Reporter
?
Pat Reavy, Crime Reporter
?
Source: http://www.ksl.com/?sid=24107868&nid=148&s_cid=rss-extlink
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PFT: Alec Ogletree charged with DUI
APA warning to the Bills not to reach for a quarterback in the draft.
Defense is where the money goes for the Dolphins.
TE Jake Ballard should be ready to compete for a job with the Patriots this offseason.
The Jets are looking for a quarterback in a bad year to be looking for a quarterback.
Ravens K Justin Tucker and WR Anquan Boldin played bubble soccer with Jimmy Fallon.
Bengals DT Domata Peko is serving as the chair of a March of Dimes Walk in April.
Mary Kay Cabot of the Cleveland Plain Dealer doesn?t think the Browns have to worry about Jimmy Haslam being an uninvolved owner.
A vote for the Steelers to find their way to selecting LB Manti Te?o in the draft.
Texans G.M. Rick Smith will receive the Charlie Ward Tribute to Excellence award.
Setting the safety market in free agency for the Colts.
Defensive line coach Todd Wash was rebuffed in his first attempt to join Gus Bradley in leaving the Seahawks for the Jaguars.
The Titans haven?t decided whether to tender an offer to C Fernando Velasco.
Jeff Legwold of the Denver Post turns in his report card for the Broncos season.
There?s no obvious quarterback choice for the Chiefs in the draft.
A call for the Raiders to reunite with S Charles Woodson.
The Chargers have options to fill the need at left tackle.
Cowboys running backs coach Gary Brown said the team wants ?to shine some things up? with DeMarco Murray.
A New Jersey firefighters union is raising money to build 26 playgrounds in honor of the Sandy Hook Elementary School shooting victims, including a football themed one in honor of Giants and Victor Cruz-fan Jack Pinto.
S Patrick Chung could be of interest to the Eagles as a free agent.
A look at combine cornerbacks that could interest the Redskins.
Bears quarterbacks coach Matt Cavanaugh says it?s too early to make his evaluation of QB Jay Cutler.
Anwar Richardson of MLive.com thinks Lions DT Ndamukong Suh should be upset that the NFL didn?t discipline Ravens CB Cary Williams for contacting an official in the Super Bowl.
The Packers are expected to talk about a long-term contract with CB Sam Shields.
Tom Powers of the Pioneer Press thinks the Vikings would be unwise to part ways with WR Percy Harvin.
Is DE Dwight Freeney a possibility for the Falcons in free agency?
Banging the drum for the Panthers to make a run for S Charles Woodson.
Former Saints DB Curtis DeLoatch reminisces about his touchdown in the first post-Katrina game in the Superdome.
The Buccaneers website found so many great offensive highlights in 2012 that they split the video into two parts.
Cardinals CB Greg Toler isn?t the biggest name in free agency, but he could be one of the bigger successes.
The Rams had new defensive coordinator Tim Walton on the radar for a while.
Tim Kawakami of the Mercury News takes a look at the 49ers? decision on QB Alex Smith.
Is Russell Wilson already the best quarterback in Seahawks history?
Source: http://profootballtalk.nbcsports.com/2013/02/16/alec-ogletree-charged-with-dui/related/
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Vatican raises possibility of early March conclave
VATICAN CITY (AP) ? The Vatican raised the possibility Saturday that the conclave to elect the next pope might start sooner than March 15, the earliest date possible under current rules that require a 15 to 20 day waiting period after the papacy becomes vacant.
Vatican spokesman the Rev. Federico Lombardi said that Vatican rules on papal succession are open to interpretation and that "this is a question that people are discussing."
Any change to the law itself would have to be approved by the pope before he resigns.
But if Vatican officials determine that the matter is just a question of interpreting the existing law, "it is possible that church authorities can prepare a proposal to be taken up by the cardinals on the first day after the papal vacancy" to move up the start of the conclave, Lombardi said.
The 15 to 20 day waiting period is in place to allow time for all cardinals who don't live in Rome to arrive, under the usual circumstance of a pope dying. But in this case the cardinals already know that this pontificate will end Feb. 28, with the resignation of Pope Benedict XVI, and therefore can get to Rome in plenty of time to take part in the conclave, Lombardi said.
The date of the conclave's start is important because Holy Week begins March 24, with Palm Sunday Mass followed by Easter Sunday on March 31. In order to have a new pope in place in time for the most solemn liturgical period on the church calendar, he would need to be installed by Sunday, March 17, because of the strong tradition to hold installation Mass on a Sunday. Given the tight time frame, speculation has mounted that some arrangement would be made to start the conclave earlier than a strict reading of the law would allow.
Questions about the start of the conclave have swirled since Benedict stunned the world on Feb. 11, by announcing that he would retire, the first pontiff in 600 years to abdicate rather than stay in office until death. His decision has created a host of questions about how the Vatican will proceed, given that its plans for the so-called "sede vacante" ? or vacant seat ? period between papacies are based on the process starting with a papal death.
"In this moment we are not prepared," said Cardinal Franc Rode, the former head of the Vatican's office for religious orders who will vote in the conclave. "We have not been able to make predictions, strategies, plans, candidates. It is too early, but we will get there. In two or three weeks things will be put in place."
Meanwhile, a German journalist who has published several long interviews with Benedict over the years suggested that the pope strongly foreshadowed his retirement during an August conversation.
Peter Seewald said in an article for the German weekly Focus published Saturday that the pontiff had told him that his strength was diminishing and "not much more" could be expected from him as pope.
"I am an old man and my strength is running out," Seewald quoted the pope as saying. "And I think what I have done is enough."
Asked by Seewald whether he was considering resignation, Benedict responded: "That depends to what extent my physical strength will compel me to." The summer interview, as well as another in December, were for a new Benedict biography.
Seewald's 2010 book-length interview with Benedict, "Light of the World," laid the groundwork for a possible resignation.
In it, he quoted Benedict as saying: "If a pope clearly realizes that he is no longer physically, psychologically and spiritually capable of handling the duties of his office, then he has a right, and under some circumstances, also an obligation to resign."
He stressed then, however, that resignation was not an option to escape a particular burden, such as the scandal over sexual abuse by clerics which had erupted earlier in 2010.
In Saturday's article, Seewald recalled asking the pope in August how badly the 2012 scandal over leaks of papal documents, in which the pope's ex-butler was convicted of aggravated theft, had affected him.
Benedict said the affair had not thrown him off his stride or made him tired of office. "It is simply incomprehensible to me," he said.
The journalist said that when he last saw Benedict about 10 weeks ago, his hearing had deteriorated and he appeared to have lost vision in his left eye, adding that the pope had lost weight and appeared tired.
Benedict, however, appeared in good form on Saturday for some of his final audiences. He met with the Guatemalan president, a group of visiting Italian bishops, and had his farewell audience with Italian Premier Mario Monti.
"He was in good condition," Guatemalan President Otto Perez Molina told reporters afterward. "He didn't seem tired, rather smiling, lively ? and happy and very clear in his decision to resign."
Cardinal Angelo Scola, the archbishop of Milan and a leading contender to succeed Benedict, said several of the visiting bishops noted at the end of their audience that they were the last group of bishops to be received by the pope. "'This responsibility means you have to become a light for all,'" he quoted Benedict as saying.
Lombardi also gave more details about Benedict's final public audiences and plans for retirement, saying already 35,000 people had requested tickets for his final general audience to be held in St. Peter's Square on Feb. 27.
He said Benedict would spend about two months in the papal summer retreat at Castel Gandolfo south of Rome immediately after his abdication, to allow enough time for renovations to be completed on his retirement home ? a converted monastery inside the Vatican walls.
That means Benedict would be expected to return to the Vatican, no longer as pope, around the end of April or beginning of May, Lombardi said.
He was asked if and when the pope would meet with his successor and whether he would participate in his installation Mass. Like many open questions about the end of Benedict's papacy, Lombardi said, both issues simply haven't been resolved.
___
Follow Nicole Winfield at www.twitter.com/nwinfield
Source: http://news.yahoo.com/vatican-raises-possibility-early-march-conclave-124446100.html
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LA Lakers owner Jerry Buss hospitalized with cancer -report
Finola Hughes has called the upcoming 50th anniversary of "General Hospital" a "really sweet" moment."I think the fact that we, at 'GH,' are doing so well right now, and to enter into our 50th anniversary on such a high, it feels really sweet," the actress, who plays Port Charles Police Chief Anna Devane, told Access Hollywood, when asked about the daytime drama's impending anniversary.
Source: http://news.yahoo.com/la-lakers-owner-jerry-buss-hospitalized-cancer-report-223807643--nba.html
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The Time Is Out of Joint
Holdups and false starts kept Voodoo from a '90s release. Perfectionist D?Angelo had become distracted by weed and weightlifting, and debilitated by sophomore pressure to follow up his groundbreaking 1995 debut Brown Sugar. In the interim he?d fathered two children, switched managers, jumped to a new record label, and made cameos on scattershot soundtracks. Two promo singles dropped: murky, sample-heavy ?Devil's Pie? in October 1998 and Redman/Method Man-assisted toe-tapper ?Left and Right? a year later. But promises of a full-length studio album evaporated into the ether. Voodoo might have seen its commercial release in November 1999, but a planned duet with Lauryn Hill on a lurching cover of Roberta Flack's 1975 ?Feel Like Making Love? remained unfinished and the album was pushed back until just after the New Year. (The rendition would ultimately wind up on Voodoo as a solo D'Angelo record without Hill.)
Voodoo was a project obsessed with 1960s, '70s, and '80s funk and soul?a nostalgic nod to the ideas and inventions of black music trailblazers like Jimi Hendrix, Sly Stone, George Clinton, Kool and the Gang, Al Green, and Prince, powered by avant-garde hip-hop-influenced rhythms. As such, Voodoo is decidedly postmodern, bopping in and out of and between eras without necessarily belonging to any singular era in particular. And perhaps the delayed, dislocated timing of Voodoo?s commercial release suggests a truism about D'Angelo himself: Wherever he seems to go, the time is, as Hamlet once said, out of joint.
Brown Sugar relied on programming, with many of the songs pre-written and arranged before D?Angelo recorded them. Voodoo, on the other hand, was a more organic, improvisatory, and experimental affair. Much of the songwriting occurred in the studio. The innovation kicked off, it seems, with Jimi Hendrix. In a recent interview, Voodoo's mix engineer Russ Elevado recounted to me how he helped turn D'Angelo onto Hendrix in the mid '90s. "All D'Angelo had heard of Jimi at that time were songs like Purple Haze and albums like Are You Experienced," he said. "I had been hired to mix a few songs on Brown Sugar; and, around '94 or '95, I kept trying to play Jimi for D'Angelo but at the time he wasn?t really open to it. Finally when I went down to Virginia to talk about the concept for what was to become Voodoo, D'Angelo and I went out for breakfast, and in the car I popped in Electric Ladyland. He looked at me as if to say: ?Who is this??"
No surprise, then, that they chose downtown New York's Electric Lady, the famed studio Hendrix built before he died, as the venue for recording the album. "There we were,? Elevado recalls, ?blowing the dust off the original Rhodes that Stevie supposedly recorded with in the early 1970s, and blowing dust off some of the microphones. You have to remember that at that time in the mid 1990s, hardly anybody in soul music was doing any recordings with vintage equipment like that.?
The concept behind Voodoo was simple. Put together a kick-ass ensemble of R&B musicians bent on grooving together. Record them live, in real time, jamming face-to-face in an effort to capture their conviviality and chemistry. This was the way funk records used to be made in the pre-digital era when people who knew what they were doing were actually making them. For Voodoo's core rhythm trio, D'Angelo recruited his friend and colleague, the Roots' Afroed visionary Ahmir "Questlove" Thompson to play drums, and Welsh journeyman Pino Palladino to hold down the bass. Additional collaborators included guitar mavens Charlie Hunter, Spanky Alford and Mike Campbell, neo-soul stalwart James Poyser on keys, and jazz prodigy Roy Hargrove on horns.
?I was a kind of a walking YouTube before YouTube existed,? said Questlove in our recent interview. ?People felt comfortable to share archives with me and trusted that I wouldn?t go out and exploit them. So I would get what I would call ?treats:? you know, an old promoter that might have worked for Bill Graham back in the day ? would hand me a manila envelope and it would be, say, a rare copy of Sly and the Family Stone?s four shows at the Fillmore. I?d take it back to Electric Lady Studios and make copies of it and we?d just study it and then a week later we?d start working on it. That was the process.? The band spent all of 1996 and most of 1997, he says, ?just watching treats and jamming. I have to say we really hit our stride in late 1997 when I went to Japan and unearthed about 4,000 video episodes of Soul Train. Then we really got down to business and started recording the album.?
"When my musician friends first heard the album, they were confused,? notes Pino Palladino. ?They thought: It sounds kinda weird, the timing?s kinda weird on it. D'Angelo explained the concept of how he wanted the bass to sound to me before we started playing. I attempted to put the bassline where I thought he wanted it. I would never have thought of putting it so far back behind the beat. But it becomes a different feeling: It stretches in and out of different accents."
Source: http://feeds.slate.com/click.phdo?i=6289ded5e5d1acc1440e31e89e1d3601
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